Endocrine Abstracts

Obesity epidemic is one of the major concerns in the world. Worryingly, a high percentage of pregnant women have obesity, which could imply several consequences. Maternal obesity leads to different abnormalities in pregnancy and delivery. In addition, recent studies show that the offspring of obese mothers has an increased probability to suffer cardiovascular, metabolic and reproductive diseases. We have previously demonstrated that exposure to a high fat diet is related to ob...

Sodium–glucose co-transporter 2 (SGLT2)-inhibitors represent a new class of drugs that inhibit glucose re-uptake in the proximal renal tubule resulting in glycosuria, with concomitant weight loss and improved glycaemic control in patients with type 2 diabetes mellitus (T2DM). Since becoming available, SGLT2 inhibitors have been implicated in over 20 reported cases of diabetic ketoacidosis or ketosis. In many cases there was an antecedent period of decreased oral intake, a...